GreenScreen® for Safer Chemicals is a method for comparative chemical hazard assessment that builds on the U.S. Environmental Protection Agency’s Design for Environment (DfE) approach and other national and international precedents including but not limited to the Organisation for Economic Cooperation and Development (OECD), Canada Domestic Substances List Methodology, the International Joint Commission, the European Union’s Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) and Classification, Labeling and Packaging (CLP) Regulations, the Stockholm Convention on Persistent Organic Pollutants and the Globally Harmonized System of Classification and Labelling of Chemicals (GHS). It is freely and publicly accessible, transparent and peer-reviewed.