Circular economy (CE) focuses on resource-productivity and eco-efficiency improvement in a comprehensive way, especially on the industrial structure optimization of new technology development and application, equipment renewal and management renovation. The leather industry on the one side boosts the local economic development, on the other side however leads to the tremendous environment pollution and biological chains destruction. The CE model has been implemented as a new way of raw materials, water and energy consumption reduction in the leather industry. Reduce, Reuse, Recycle and Recover of the tannery effluents have been discussed in detail according to the different operation processes. The successful treatment approaches with analysis in the aspects such as wastewater, solid waste, sulfide, Chemical Oxygen Demand (COD), ammonium salt, chloride and chrome of the leather tannery with CE model provide guidance for the sustainable development of leather industry in the future.